Archive for September, 2008

Is it a social conscience or self-interest that should motivate us to dispose of medications safely?

Monday, September 22nd, 2008

It is funny and amusing to browse around the internet. There is always somebody thinking something interesting somewhere in the world. All you have to do is to find him or her. Take just one story from California as an example. You could, of course, get in your car and drive down to your local pharmacy. Many offer a service to dispose of old and unwanted medications for you. But, the majority of us probably find the effort involved a deterrent. Why go to so much effort when you have a dumpster just outside your door? Who cares anyway? Do you ever wonder what happens after casual disposal? Your local waste management authority comes round to collect the refuse which is then dumped. There is little or no effort to sort the waste. Most authorities simply drive to the nearest landfill site and tip each load on to the growing mound of other rubbish. This pile then rots down as rain washes through it so, sooner or later, dissolved drugs end up in the watertable and potentially get recycled into your drinking water. The medications flushed go more directly into the water supply. So here is the worry. The rivers downstream from you supply water to the local towns and cities. That water supply contains what the experts call a “sub-lethal” cocktail of antibiotics, sedatives, painkillers, hormones and whatever else you so casually threw away. Ambien is, of course, a nonbenzodiazepine hypnotic. I am never reassured by the prefix “non”. In fact, Ambien works in exactly the same way as a conventional benzodiazepine and is probably just as addictive. For this reason, Ambien is listed by the Federal Drug Agency as a controlled substance. You will be pleased and delighted to know that the US Government has your interests at heart. It always wants to protect you and the environment. State and Federal regulations limit the handling and disposal of controlled substances to DEA-authorised individuals and organisations. The DEA’s Office of Diversion Control aims to prevent the diversion of legitimately manufactured (or used) controlled substances into the illegal drug traffic. If there is no-one else immediately available to handle the disposal, the controlled substances should be collected by a law enforcement officer. So, if your local pharmacy has not registered with the DEA, their only way of disposing of your unwanted drugs is to call the cops. No wonder they looked so pleased when you asked. Over the first fifteen months of the program, local citizens have deposited 1,800 pounds of medications (not all Ambien, of course). And do we really want all those bacteria out there to get used to all those antibiotics in the water? If you don’t know the answers to these and other questions of social conscience (or self-interest), take an cheap Ambien and sleep on it.

What to do about neuropathic pain?

Tuesday, September 9th, 2008

There has been a wealth of research into what causes chronic pain. It is a symptom or warning of an underlying medical problem. Medics can provide a research and study some new properties of this phenomena. Unfortunately, despite our better understanding of what it is, actually relieving the pain remains a challenge. If we are dealing with a non-fatal physical injury, we can set the broken bones, stitch up the wounds and wait for the body to repair itself. During this time, the pain management choices for doctors focus on the various side effects of the medications, the interactions between medications, etc. If the pain becomes more severe due to a terminal condition, the issues of addiction and, to some extent, adverse side effects are less relevant. The humanitarian need is to make a person as comfortable as possible during the final period of life. The cause may be a physical injury or a disease may affect the way it works. Physical injuries to the nervous system are very difficult to treat because nerve tissue does not easily regenerate. In other cases, researchers do not properly understand why an apparently undamaged system may malfunction. Because the system that transmits and controls pain sensations may be damaged or not working properly, people often react to treatment in a wide variety of unpredictable ways. But the consequences of not providing effective pain relief can be serious. People who experience pain over a longer period of time are more likely to become depressed and may find it difficult to remain in paid work.

One of the main difficulties in treating neuropathic pain is that the usual opioid analgesics do not work well. Consequently, it can take longer for the medication to reach a stable and effective level in the blood stream. During the slow build up of the drug, people can become discouraged and either want to switch to another drug thought better or discontinue use of the immediate drug. In clinical trials of the opioids, more than a quarter of participants withdrew because of the physical and psychological side effects.

But tramadol is an atypical opioid and its ability to relieve pain of all kinds makes it one of the first-response medications for the treatment of neuropathic pain. The other most common problem is that anyone with a history of seizures or who is being treated with medications that lower the seizure threshold may be at an increased risk of seizures if they are taking ultram. However, ultram is generally preferred in cases of neuropathic pain because there are fewer problems of dependence so long as people use the medication as prescribed. In other words, the balance of advantages against disadvantages usually supports the use of ultram for the treatment of neuropathic pain.

Slow release in every sense of the words.

Saturday, September 6th, 2008

Lets think that it is approved in the US and go back to the initial statement about dosage. At present, it is easy for people to forget when a dose is due. Less of a problem is taking too little. Taking too much is always a problem. Because many of the people taking ultram are older, forgetfulness is more common. Further, if a patient is on a four-hour schedule, this means waking during the night to maintain the required blood concentration. Manufacturer believes that a once-daily regime will improve compliance. The evidence from the European markets on this point is encouraging.

The simple rule is that the dose should be individualised so that each person takes the smallest dose required to produce the required pain relief. Normally, this means that patients start with a very low daily dose and slowly increase the dosage every three days until a stable and effective concentration in the blood stream is achieved. After that, the level is maintained by taking one tablet every four to five or six hours. No one should take more than 400mg per day. If there is a more urgent need for pain relief and that need outweighs the risk of dependence, people may take an initial high dosage. This well-established system may be about to change in the US.

This has been an unusually slow process. The company originally planned the product launch for September 2006, but the FDA has required more clinical trials to be undertaken as a precondition of taking the approval process forward. Although it is good that the FDA has become more cautious in giving approval to new products, this is a variation on a well-established product. Applying the same caution may seem somewhat unfair given the significant increase in the cost of the process. According to Labopharm Inc. the FDA gave notice in May 2007 that a different statistical method was to be used to analyse the pain. This required further testing to produce more data compatible with the new method. The disagreement about methodology affected the extent to which the company could rely only on data produced from those completing the trials. The FDA was concerned that the exclusion of data from those dropping out of the trials could skew the results on safety.

Take Acomplia and lose weight the easy way

Wednesday, September 3rd, 2008

No, this is not time travel back to Seckond World War although with the characters involved, it’s like the plot for a Hollywood movie. There’s this overpaid Brit who plays this weird game they call football. This is the game played by women over here in the US. I think our girls won a gold medal at the Olympics a few days ago, but that Beckham is not a girl, of course, although he does wear a sarong (that’s a skirt for men). This Beckham guy is hanging out with the stars in LA and now Tom Cruise is boasting that he’s lost 10 pounds in six weeks thanks to Beckham’s advice. So kicking a ball help you lose weight. You don’t have to be a scientologist to figure that one out. But Cruise has been under pressure from Katie Holmes who’s fifteen years younger than him. Love handles aren’t that sexy, even in a movie star. But, gotta give Cruise credit. Most other A-listers would have been quietly popping pills like Acomplia - the top European weight loss pills. But Beckham must have a diet book coming out, so Cruise is out there pitching for him. If he has lost weight, perhaps he’s quietly taking Acomplia. But let’s not go there. The moral of this is: if you can’t hang out with top Brit footballers who dress like girls, you can take Acomplia and lose weight the easy way.

History: treatment of ED.

Monday, September 1st, 2008

Mankind has met the problem of erectial disfunction long time before urologists discovered underlying reasons of such disease.

Innumerable substances have been used to increase sexual performance. Oysters, lobsters, eggs, and spices are examples. Spanish Fly, a substance made by grinding the wings of certain beetles, was a favorite of that party animal, the Marquis de Sade. It is illegal in the United States both because of the unproven nature of its effectiveness and a tendency to cause seizures or death. Rhinoceros horn has been used (unsuccessfully) for so long that its name has become synonymous with sexual arousal. Unfortunately, its popularity has led to such widespread slaughter of the animals that they face extinction. Ancient Egyptians believed eating crocodile penises increased virility. Anyone capable of eating a crocodile’s penis probably didn’t need any more help proving his manhood.

Surgery/Transplants

The idea of using animal testes to treat impotence began in the Middle Ages, when a standard treatment for “the male malady” was to place the testicles of a cock under the bed. Another option was eating the rooster’s testes. You could guess that putting them under the bed was much more popular. The Malleus Maleficarum was a guide to witchcraft during that era that asserted witch’s spells caused impotence. This was the major reason for this to spread all over the world. French physiologist Charles Edouard Brown-Sequard injected himself in the 1880s with an extract from the testicles of dogs that he claimed made him smarter, stronger, and more virile. After ten injections, he reported improved erections, as well as a stronger jet of urine and “power of defecation.” He made no claims about the effect this had on the dogs. His “Elixir of Life” became an instant best-seller. Its 1889 launch rivaled that of medication, even without a famous spokesman.

Eugen Steinach in 1920 pioneered surgical treatment of impotence with a revolutionary idea-vasectomy. He believed blocking the vas deferens (the tubes semen passes through) would force maleness factors back into the bloodstream instead of letting them go to waste on the sheets. The erections probably weren’t much better, but with female partners spending less time pregnant, there was much more opportunity. Two recipients of the Steinach procedure were Sigmund Freud and Nobel Prize winner William Butler Yeats. Freud, the person most responsible for the mistaken impression that impotence was primarily psychological, set back our understanding of the disorder by decades. Taking him out of the gene pool probably did more to help the science of impotence therapy than anything else Steinach did. Many respected universities have subsequently been involved in the transplantation of animal or human testicular tissue. Swiss professor Paul Niehans treated tens of thousands of men with testicular cell injections in the early twentieth century. His procedure sometimes went straight to the root of the problem by injecting a booster shot directly into the patient’s testes. He transplanted them into other, more fortunate (albeit impotent) prisoners, reporting improvement in strength, well-being, and libido among the recipients. When the supply ran low, he substituted goat, ram, boar, and deer testicular tissue. Why he wanted to improve libido among prisoners is still not evident. It remains unclear whether any of these early attempts at treating impotence with human or animal testicular tissue actually worked. Most of the researchers mentioned eventually fell into disrepute-but at least Aristotle Onassis got the girl.

Mechanical

Medieval times knew many mature ways to treat ED. No one wanted a second treatment, so failures went unreported. Many types of splints have been used, including hollowed-out antlers and horns. Encouraged by finding the penis bone (baculum) in some animals, early surgeons placed rib cartilage into the penis. Although these initial attempts failed, penile prostheses have more recently proven particularly reliable.